Muscadines are notoriously hard to root from hardwood cuttings. Under perfect conditions one in a hundred might root. For the home grower the easiest way to propagate them is by air layering. Commercial growers propagate them from softwood cuttings, but you need to be set up with a greenhouse and misters to do that successfully.
In my opinion the best resource for Muscadines is Ison Nursery out of Brooks Georgia. I'm not remembering Mr. Ison's first name right now, but if you have he's the one to talk to.
I have five mature vines myself, and 7 that are immature. So far my favorite variety by a long shot is Supreme. However, the Supreme Muscadine has a notorious reputation for only doing well in Georgia. She is a female and would have to be accompanied by a self fertile variety in order to produce. The Supreme on account of the size and quantity of fruit has special pruning requirements.
Muscadines vary a lot in quality. They are also big plants and take up lots of space. It is worth the few extra dollars to get the newer state of the art varieties from Ison's rather than just planting an unknown which might or might not have quality fruit.
Muscadines do best when grown on a 20 foot single wire trellis. They have to be pruned every year in late winter to be productive. There are lots and lots of videos on YouTube about how to do this. If I lived in the SE somewhere outside Georgia and had space for only two muscadines I would get Black Beauty (female) and Lane (self fertile). Lane is a brand new introduction, is a seedling of Suprem and is reported to have fruit size and quality nearly equal to supreme which is almost unthinkable for a self fertile variety. It's also a very early season variety while Black Beauty is a mid to late season variety. My Black Beauty starts ripening fruit at about the time that Supreme is just about finished. The berries are almost as big and sweet, but Black Beauty is reportedly much easier to grow outside Georgia. I live in SE Georgia so my Supreme does great. My Lane when into the ground this year, so it will be three years before I can say much about it. God bless.
Marcus